Izzie bites off more than she can chew on her first day of chemotherapy, Mark and Derek are forced to work on the same patient, Meredith's plans for a simple wedding take a turn, and Karev finds himself split between worry over Izzie and excelling as a resident.
Stars: Ellen Pompeo, Sandra Oh, Katherine Heigl
Director(s): Tony Phelan
Writer(s): Shonda Rhimes, Sonay Hoffman, Peter Nowalk